Scientific Articles

iScience/2025

Molinari P, Verlato A, Noble J …
Caloric restriction protects from acute and chronic kidney injury by inhibiting monocyte recruitment
iScience, 2025; 28

Science Translational Medicine/2024

Villani et al., Sci. Transl. Med. A kidney- specific fasting- mimicking diet induces podocyte reprogramming and restores renal function in glomerulopathy

Cell Metabolism/2024

Koppold DA et al. “International consensus on fasting terminology.” Cell Metab. 2024 Aug 6;36(8):1779-1794.e4. doi: 10.1016/j.cmet.2024.06.013. Epub 2024 Jul 25. PMID: 39059384; PMCID: PMC11504329.

Cell Metabolism/2024

Brandhorst S and Longo VD (2024) Exploring juventology: unlocking the secrets of youthspan and longevity programs. Front. Aging 5:1379289. doi: 10.3389/fragi.2024.1379289

INTERNATIONAL JOURNAL OF CANCER/2024

Ligorio, Francesca et al. “Adding fasting-mimicking diet to first-line carboplatin-based chemotherapy is associated with better overall survival in advanced triple-negative breast cancer patients: A subanalysis of the NCT03340935 trial.” International journal of cancer vol. 154,1 (2024): 114-123. doi:10.1002/ijc.34701

CANCER RESEARCH/2024

Raucci, Franca et al. “Cyclic Fasting-Mimicking Diet Plus Bortezomib and Rituximab Is an Effective Treatment for Chronic Lymphocytic Leukemia.” Cancer research vol. 84,7 (2024): 1133-1148. doi:10.1158/0008-5472.CAN-23-0295

CANCERS/2024

Buono, Roberta et al. “Fasting-Mimicking Diet Inhibits Autophagy and Synergizes with Chemotherapy to Promote T-Cell-Dependent Leukemia-Free Survival.” Cancers vol. 15,24 5870. 16 Dec. 2023, doi:10.3390/cancers15245870

EUROPEAN JOURNAL OF CANCER/2022

Ligorio, Francesca et al. “Exceptional tumour responses to fasting-mimicking diet combined with standard anticancer therapies: A sub-analysis of the NCT03340935 trial.” European journal of cancer (Oxford, England : 1990) vol. 172 (2022): 300-310. doi:10.1016/j.ejca.2022.05.046

CELL REPORTS/2022

Cortellino, Salvatore et al. “Fasting renders immunotherapy effective against low-immunogenic breast cancer while reducing side effects.” Cell reports vol. 40,8 (2022): 111256. doi:10.1016/j.celrep.2022.111256

AGING CELL/2022

Rahmani, Jamal et al. “Association between IGF-1 levels ranges and all-cause mortality: A meta-analysis.” Aging cell vol. 21,2 (2022): e13540. doi:10.1111/acel.13540

CANCER DISCOVERY/2022

Vernieri, Claudio et al. “Fasting-Mimicking Diet Is Safe and Reshapes Metabolism and Antitumor Immunity in Patients with Cancer.” Cancer discovery vol. 12,1 (2022): 90-107. doi:10.1158/2159-8290.CD-21-0030

CANCERS/2021

Valdemarin, Francesca et al. “Safety and Feasibility of Fasting-Mimicking Diet and Effects on Nutritional Status and Circulating Metabolic and Inflammatory Factors in Cancer Patients Undergoing Active Treatment.” Cancers vol. 13,16 4013. 9 Aug. 2021, doi:10.3390/cancers13164013

NATURE/2020

Caffa, Irene et al. “Author Correction: Fasting-mimicking diet and hormone therapy induce breast cancer regression.” Nature vol. 588,7839 (2020): E33. doi:10.1038/s41586-020-2957-6

BREAST CANCER RESEARCH AND TREATMENT/2021

Lugtenberg, Rieneke T et al. “Quality of life and illness perceptions in patients with breast cancer using a fasting mimicking diet as an adjunct to neoadjuvant chemotherapy in the phase 2 DIRECT (BOOG 2013-14) trial.” Breast cancer research and treatment vol. 185,3 (2021): 741-758. doi:10.1007/s10549-020-05991-x

NATURE COMMUNICATIONS/2020

de Groot, Stefanie et al. “Fasting mimicking diet as an adjunct to neoadjuvant chemotherapy for breast cancer in the multicentre randomized phase 2 DIRECT trial.” Nature communications vol. 11,1 3083. 23 Jun. 2020, doi:10.1038/s41467-020-16138-3

NATURE COMMUNICATIONS/2020

Di Tano, Maira et al. “Synergistic effect of fasting-mimicking diet and vitamin C against KRAS mutated cancers.” Nature communications vol. 11,1 2332. 11 May. 2020, doi:10.1038/s41467-020-16243-3

Nature Review Cancer / 2018
Fasting and cancer: molecular mechanisms and clinical application.

BMC CANCER / 2018
The effects of short-term fasting on quality of life and tolerance to chemotherapy in patients with breast and ovarian cancer: a randomized cross-over pilot study

Stephan P. Bauersfeld1, Christian S. Kessler1,2, Manfred Wischnewsky3, Annette Jaensch2, Nico Steckhan1, Rainer Stange1,2, Barbara Kunz2, Barbara Brückner4, Jalid Sehouli5 and Andreas Michalsen1,2

JOP. Journal of the Pancreas / 2018
Long-Term Outcomes of the Treatment of Unresectable (StageIII- IV) Ductal Pancreatic Adenocarcinoma Using Metabolically Supported Chemotherapy (MSCT): A Retrospective Study

CELL PRESS / 2018
Starvation, Stress Resistance, and Cancer

SCIENTIFIC REPORTS / 2017
Effects of Prolonged GRP78 Haploinsufficiency on Organ Homeostasis, Behavior, Cancer and Chemotoxic Resistance in Aged Mice

PLOS|BIOLOGY / 2017

Fasting regulates EGR1 and protects from glucose- and dexamethasone-dependent sensitization to chemotherapy

ELSEVIER / 2017
Protective effects of short-term dietary restriction in surgical stress and chemotherapy

SCIENTIFIC REPORTS / 2017
Effects of Prolonged GRP78 Haploinsufficiency on Organ Homeostasis, Behavior, Cancer and Chemotoxic Resistance in Aged Mice

AACR / 2016
Targeting Cancer Metabolism: Dietary and Pharmacologic Interventions

BIOMED CENTRAL / 2016
Safety and feasibility of fasting in combination with platinum based chemotherapy

CELL PRESS / 2016
Fasting-Mimicking Diet Reduces HO-1 to Promote T Cell-Mediated Tumor Cytotoxicity

ELSEVIER / 2016
Growth factors, aging and age-related diseases

BMC CANCER / 2015
The effects of short-term fasting on tolerance to (neo) adjuvant chemotherapy in HER2-negative breast cancer patients: a randomized pilot study

Stefanie de Groot1, Maaike PG Vreeswijk2, Marij JP Welters1, Gido Gravesteijn2, Jan JWA Boei2, Anouk Jochems1, Daniel Houtsma3, Hein Putter4, Jacobus JM van der Hoeven1, Johan WR Nortier1, Hanno Pijl5 and Judith R Kroep1

IMPACT JOURNALS / 2015
Fasting potentiates the anticancer activity of tyrosine kinase inhibitors by strengthening MAPK signaling inhibition

IMPACT JOURNALS / 2015
Fasting induces anti-warburg effect that increases respiration but reduces ATP-synthesis to promote apoptosis in colon cancer models

ELSEVIER / 2013
Short-term calorie and protein restriction provide partial protection from chemotoxicity but do not delay glioma progression

DISCOVER / 2013
A small group of Ecuadorians with rare genetic disorder could hold a key to cancer and other age-related illness.

NATIONAL INSTITUTE OF HEALTH / 2013
Aging, Nutrient Signaling, Hematopoietic Senescence, and Cancer

SCIENCE TRANSLATIONAL MEDICINE / 2012
Fasting Cycles Retard Growth of Tumors and Sensitize a Range of Cancer Cell Types to Chemotherapy

ELSEVIER / 2012
Starvation, detoxification, and multi drug resistance in cancer therapy

PLOS / 2012
Fasting Enhances the Response of Glioma to Chemo and Radiotherapy

C Lee and VD Longo / 2011
Fasting vs dietary restriction in cellular protection and cancer treatment:from model organisms to patients

JOVE / 2011
Video ArticleStudying Age-dependent Genomic Instability using theS. cerevisiae Chronological Lifespan Model

CANCER RESEARCH / 2010
Reduced Levels of IGF-I Mediate Differential Protection of Normal and Cancer Cells in Response to Fastingand Improve Chemotherapeutic Index

JCB / 2009
Oncogene homologue Sch9 promotes age-dependent mutations by a superoxide and Rev1/Pol-dependent mechanism

IMPACT AGING / 2009
Fasting and cancer treatment in humans: A case series report

PNAS / 2008
Starvation-dependent differential stress resistanceprotects normal but not cancer cells againsthigh-dose chemotherapy

PERSPECTIVES / 2008
Turning anti aging genes against cancer

JCB / 2008
Longevity mutation in SCH9 prevents recombination errors and premature genomic instability in a Werner/Bloom model system

ELSEVIER / 2007
A simple model system for age-dependent DNA damage and cancer

BMC Genomics / 2007
Cheng, C., Fabrizio, P., Ge, H. et al. Inference of transcription modification in long-live yeast strains from their expression profiles. BMC Genomics 8, 219 (2007). https://doi.org/10.1186/1471-2164-8-219

Methods in Molecular Biology: Biological Aging: Methods and Protocols / 2006
Paola Fabrizio and Valter D. Longo: The Chronological Life Span of Saccharomyces cerevisiae

Nature Reviews Genetics / 2005
Valter D. Longo, Joshua Mitteldorf and Vladimir P. Skulachev. “Programmed and altruistic ageing”

The Journal of Cell Biology / 2004
Superoxide is a mediator of an altruistic aging program in Saccharomyces cerevisiae

THE JOURNAL OF BIOLOGICAL CHEMISTRY / 2004
Wallace MA, Liou LL, Martins J, Clement MH, Bailey S, Longo VD, Valentine JS, Gralla EB. Superoxide inhibits 4Fe-4S cluster enzymes involved in amino acid biosynthesis. Cross-compartment protection by CuZn-superoxide dismutase. J Biol Chem. 2004 Jul 30;279(31):32055-62. doi: 10.1074/jbc.M403590200. Epub 2004 May 27. PMID: 15166213.

Experimental Gerontology / 2003
Valter D. Longo. The Ras and Sch9 pathways regulate stress resistance and longevity

Aging Cell / 2003
Paola Fabrizio and Valter D. Longo.
The chronological life span of Saccharomyces cerevisiae

Mechanisms of Ageing and Development / 2003
Biodemographic trajectories of age-specific reproliferation from stationary phase in the yeast Saccharomyces cerevisiae seem multiphasic

Science / 2001
Regulation of Longevity and
Stress Resistance by Sch9 in Yeast

Archives of Biochemistry and Biophysics / 1999
Longo et al. “Mitochondrial Superoxide Decreases Yeast Survival in Stationary Phase”

Science / 1998
James W. Vaupel, et al. “Biodemographic Trajectories of Longevity”

THE JOURNAL OF BIOLOGICAL CHEMISTRY / 1996
Superoxide Dismutase Activity Is Essential for Stationary Phase Survival in Saccharomyces cerevisiae