Cancer

NATURE/2026

Padrão, N., Severson, T.M., Gregoricchio, S. et al. Fasting boosts breast cancer therapy efficacy via glucocorticoid activation. Nature 649, 1013–1021 (2026). https://doi.org/10.1038/s41586-025-09869-0

ANNALS OF ONCOLOGY/2025

Provenzano L, Dieci M, Curigliano G…
Real-world effectiveness comparison of first-line palbociclib, ribociclib or abemaciclib plus endocrine therapy in advanced HR-positive/HER2-negative BC patients: results from the multicenter PALMARES-2 study. Annals of Oncology, 2025; 36, 762-774

CELL PRESS/2025

Ligorio F, Vingiani A, Torelli T …
Early downmodulation of tumor glycolysis predicts response to fasting-mimicking diet in triple-negative breast cancer patients
Cell Metabolism, 2024; 37, 330-344.e7

NATURE – Scientific Reports/2025

Castagnoli, L., Bonì, F., Bigliardi, M. et al. Identification of new selective CD36 inhibitors to potentiate HER2-targeted therapy in HER2-positive breast cancer. Sci Rep 15, 28709 (2025). https://doi.org/10.1038/s41598-025-14639-z

Journal of Experimental & Clinical Cancer Research/2025

Castagnoli, L., Franceschini, A., Cancila, V. et al. Correction: CD36 enrichment in HER2-positive mesenchymal stem cells drives therapy refractoriness in breast cancer. J Exp Clin Cancer Res 44, 165 (2025). https://doi.org/10.1186/s13046-025-03426-3

Journal of Experimental & Clinical Cancer Research/2025

Castagnoli, L., Franceschini, A., Cancila, V. et al. CD36 enrichment in HER2-positive mesenchymal stem cells drives therapy refractoriness in breast cancer. J Exp Clin Cancer Res 44, 19 (2025). https://doi.org/10.1186/s13046-025-03276-z

Drug Resistance Updates/2025

Sebastian Brandhorst, Valter D. Longo,
Fasting-mimicking diet potentiates anti-tumor effects of CDK4/6 inhibitors against breast cancer by suppressing NRAS- and IGF1-mediated mTORC1 signaling,
Drug Resistance Updates, Volume 78, 2025, 101182, ISSN 1368-7646,
https://doi.org/10.1016/j.drup.2024.101182.

CANCER RESEARCH/2025

Raucci F, Vernieri C, Di Tano M, Ligorio F, Blaževitš O, Lazzeri S, Shmahala A, Fragale G, Salvadori G, Varano G, Casola S, Buono R, Visco E, de Braud F, Longo VD. Cyclic Fasting-Mimicking Diet Plus Bortezomib and Rituximab Is an Effective Treatment for Chronic Lymphocytic Leukemia. Cancer Res. 2024 Apr 1;84(7):1133-1148. doi: 10.1158/0008-5472.CAN-23-0295. PMID: 38241703; PMCID: PMC10982641.

Biomedical Journal/2025

M.G. Mirisola, V.D. Longo,
Inactivation of Ymr1, Sjl2/3 phosphatases promotes stress resistance and longevity in wild type and Ras2G19V yeast,
Biomedical Journal, Volume 47, Issue 2, 2024, 100694,
ISSN 2319-4170,
https://doi.org/10.1016/j.bj.2023.100694.

INTERNATIONAL JOURNAL OF CANCER/2024

Ligorio, Francesca et al. “Adding fasting-mimicking diet to first-line carboplatin-based chemotherapy is associated with better overall survival in advanced triple-negative breast cancer patients: A subanalysis of the NCT03340935 trial.” International journal of cancer vol. 154,1 (2024): 114-123. doi:10.1002/ijc.34701

INTERNATIONAL JOURNAL OF CANCER/2024

Ligorio, Francesca et al. “Adding fasting-mimicking diet to first-line carboplatin-based chemotherapy is associated with better overall survival in advanced triple-negative breast cancer patients: A subanalysis of the NCT03340935 trial.” International journal of cancer vol. 154,1 (2024): 114-123. doi:10.1002/ijc.34701

CANCER RESEARCH/2024

Raucci, Franca et al. “Cyclic Fasting-Mimicking Diet Plus Bortezomib and Rituximab Is an Effective Treatment for Chronic Lymphocytic Leukemia.” Cancer research vol. 84,7 (2024): 1133-1148. doi:10.1158/0008-5472.CAN-23-0295

CANCERS/2024

Buono, Roberta et al. “Fasting-Mimicking Diet Inhibits Autophagy and Synergizes with Chemotherapy to Promote T-Cell-Dependent Leukemia-Free Survival.” Cancers vol. 15,24 5870. 16 Dec. 2023, doi:10.3390/cancers15245870

JNCI: Journal of the National Cancer Institute/2022

Ligorio, Francesca et al. Predictive Role of CD36 Expression in HER2-Positive Breast Cancer Patients Receiving Neoadjuvant Trastuzumab, JNCI: Journal of the National Cancer Institute, Volume 114, Issue 12, December 2022, Pages 1720–1727, https://doi.org/10.1093/jnci/djac126

EUROPEAN JOURNAL OF CANCER/2022

Ligorio, Francesca et al. “Exceptional tumour responses to fasting-mimicking diet combined with standard anticancer therapies: A sub-analysis of the NCT03340935 trial.” European journal of cancer (Oxford, England : 1990) vol. 172 (2022): 300-310. doi:10.1016/j.ejca.2022.05.046

NATURE/2022

Fay-Watt, V., O’Connor, S., Roshan, D. et al. The impact of a fasting mimicking diet on the metabolic health of a prospective cohort of patients with prostate cancer: a pilot implementation study. Prostate Cancer Prostatic Dis 26, 317–322 (2023). https://doi.org/10.1038/s41391-022-00528-3

CELL REPORTS/2022

Cortellino, Salvatore et al. “Fasting renders immunotherapy effective against low-immunogenic breast cancer while reducing side effects.” Cell reports vol. 40,8 (2022): 111256. doi:10.1016/j.celrep.2022.111256

AGING CELL/2022

Rahmani, Jamal et al. “Association between IGF-1 levels ranges and all-cause mortality: A meta-analysis.” Aging cell vol. 21,2 (2022): e13540. doi:10.1111/acel.13540

CANCER DISCOVERY/2022

Vernieri, Claudio et al. “Fasting-Mimicking Diet Is Safe and Reshapes Metabolism and Antitumor Immunity in Patients with Cancer.” Cancer discovery vol. 12,1 (2022): 90-107. doi:10.1158/2159-8290.CD-21-0030

CANCERS/2021

Valdemarin, Francesca et al. “Safety and Feasibility of Fasting-Mimicking Diet and Effects on Nutritional Status and Circulating Metabolic and Inflammatory Factors in Cancer Patients Undergoing Active Treatment.” Cancers vol. 13,16 4013. 9 Aug. 2021, doi:10.3390/cancers13164013

BREAST CANCER RESEARCH AND TREATMENT/2021

Lugtenberg, Rieneke T et al. “Quality of life and illness perceptions in patients with breast cancer using a fasting mimicking diet as an adjunct to neoadjuvant chemotherapy in the phase 2 DIRECT (BOOG 2013-14) trial.” Breast cancer research and treatment vol. 185,3 (2021): 741-758. doi:10.1007/s10549-020-05991-x

NATURE/2020

Caffa, Irene et al. “Author Correction: Fasting-mimicking diet and hormone therapy induce breast cancer regression.” Nature vol. 588,7839 (2020): E33. doi:10.1038/s41586-020-2957-6

NATURE/2020

Caffa, I., Spagnolo, V., Vernieri, C. et al. Fasting-mimicking diet and hormone therapy induce breast cancer regression. Nature 583, 620–624 (2020). https://doi.org/10.1038/s41586-020-2502-7

NATURE COMMUNICATIONS/2020

Vernieri, C., Ligorio, F., Zattarin, E. et al. Fasting-mimicking diet plus chemotherapy in breast cancer treatment. Nat Commun 11, 4274 (2020). https://doi.org/10.1038/s41467-020-18194-1

NATURE COMMUNICATIONS/2020

de Groot, Stefanie et al. “Fasting mimicking diet as an adjunct to neoadjuvant chemotherapy for breast cancer in the multicentre randomized phase 2 DIRECT trial.” Nature communications vol. 11,1 3083. 23 Jun. 2020, doi:10.1038/s41467-020-16138-3

NATURE COMMUNICATIONS/2020

de Groot, Stefanie et al. Supplementary Information:
Fasting mimicking diet as an adjunct to neoadjuvant chemotherapy for breast cancer: DIRECT
(BOOG 2013-04).
Stefanie de Groot et al.

NATURE COMMUNICATIONS/2020

Di Tano, Maira et al. “Synergistic effect of fasting-mimicking diet and vitamin C against KRAS mutated cancers.” Nature communications vol. 11,1 2332. 11 May. 2020, doi:10.1038/s41467-020-16243-3

Nature Review Cancer / 2018
Fasting and cancer: molecular mechanisms and clinical application.

BMC CANCER / 2018
The effects of short-term fasting on quality of life and tolerance to chemotherapy in patients with breast and ovarian cancer: a randomized cross-over pilot study

Stephan P. Bauersfeld1, Christian S. Kessler1,2, Manfred Wischnewsky3, Annette Jaensch2, Nico Steckhan1, Rainer Stange1,2, Barbara Kunz2, Barbara Brückner4, Jalid Sehouli5 and Andreas Michalsen1,2

JOP. Journal of the Pancreas / 2018
Long-Term Outcomes of the Treatment of Unresectable (StageIII- IV) Ductal Pancreatic Adenocarcinoma Using Metabolically Supported Chemotherapy (MSCT): A Retrospective Study

CELL PRESS / 2018
Starvation, Stress Resistance, and Cancer

Science Translational Medicine / 2017
Min Wei et al. ,Fasting-mimicking diet and markers/risk factors for aging, diabetes, cancer, and cardiovascular disease.Sci. Transl. Med.9,eaai8700(2017).DOI:10.1126/scitranslmed.aai8700

SCIENTIFIC REPORTS / 2017
Effects of Prolonged GRP78 Haploinsufficiency on Organ Homeostasis, Behavior, Cancer and Chemotoxic Resistance in Aged Mice

PLOS|BIOLOGY / 2017

Fasting regulates EGR1 and protects from glucose- and dexamethasone-dependent sensitization to chemotherapy

ELSEVIER / 2017
Protective effects of short-term dietary restriction in surgical stress and chemotherapy

SCIENTIFIC REPORTS / 2017
Effects of Prolonged GRP78 Haploinsufficiency on Organ Homeostasis, Behavior, Cancer and Chemotoxic Resistance in Aged Mice

AACR / 2016
Targeting Cancer Metabolism: Dietary and Pharmacologic Interventions

BIOMED CENTRAL / 2016
Safety and feasibility of fasting in combination with platinum based chemotherapy

CELL PRESS / 2016
Fasting-Mimicking Diet Reduces HO-1 to Promote T Cell-Mediated Tumor Cytotoxicity

ELSEVIER / 2016
Growth factors, aging and age-related diseases

BMC CANCER / 2015
The effects of short-term fasting on tolerance to (neo) adjuvant chemotherapy in HER2-negative breast cancer patients: a randomized pilot study

Stefanie de Groot1, Maaike PG Vreeswijk2, Marij JP Welters1, Gido Gravesteijn2, Jan JWA Boei2, Anouk Jochems1, Daniel Houtsma3, Hein Putter4, Jacobus JM van der Hoeven1, Johan WR Nortier1, Hanno Pijl5 and Judith R Kroep1

IMPACT JOURNALS / 2015
Fasting potentiates the anticancer activity of tyrosine kinase inhibitors by strengthening MAPK signaling inhibition

IMPACT JOURNALS / 2015
Fasting induces anti-warburg effect that increases respiration but reduces ATP-synthesis to promote apoptosis in colon cancer models

ELSEVIER / 2013
Short-term calorie and protein restriction provide partial protection from chemotoxicity but do not delay glioma progression

DISCOVER / 2013
A small group of Ecuadorians with rare genetic disorder could hold a key to cancer and other age-related illness.

NATIONAL INSTITUTE OF HEALTH / 2013
Aging, Nutrient Signaling, Hematopoietic Senescence, and Cancer

SCIENCE TRANSLATIONAL MEDICINE / 2012
Fasting Cycles Retard Growth of Tumors and Sensitize a Range of Cancer Cell Types to Chemotherapy

ELSEVIER / 2012
Starvation, detoxification, and multi drug resistance in cancer therapy

PLOS / 2012
Fasting Enhances the Response of Glioma to Chemo and Radiotherapy

C Lee and VD Longo / 2011
Fasting vs dietary restriction in cellular protection and cancer treatment:from model organisms to patients

JOVE / 2011
Video ArticleStudying Age-dependent Genomic Instability using theS. cerevisiae Chronological Lifespan Model

CANCER RESEARCH / 2010
Reduced Levels of IGF-I Mediate Differential Protection of Normal and Cancer Cells in Response to Fastingand Improve Chemotherapeutic Index

JCB / 2009
Oncogene homologue Sch9 promotes age-dependent mutations by a superoxide and Rev1/Pol-dependent mechanism

IMPACT AGING / 2009
Fasting and cancer treatment in humans: A case series report

PNAS / 2008
Starvation-dependent differential stress resistanceprotects normal but not cancer cells againsthigh-dose chemotherapy

PERSPECTIVES / 2008
Turning anti aging genes against cancer

JCB / 2008
Longevity mutation in SCH9 prevents recombination errors and premature genomic instability in a Werner/Bloom model system

Mechanisms of Ageing and Development / 2007
F. Madia, C. Gattazzo, P. Fabrizio, V.D. Longo,
A simple model system for age-dependent DNA damage and cancer,
Mechanisms of Ageing and Development,
Volume 128, Issue 1, 2007, Pages 45-49, ISSN 0047-6374,
https://doi.org/10.1016/j.mad.2006.11.009.

ELSEVIER / 2007
A simple model system for age-dependent DNA damage and cancer

CELL / 2006
Longo V, Kennedy B
Sirtuins in Aging and Age-Related Disease
Cell, 126, 257-268r

Annals of the New York Academy of Sciences / 2005
Skulachev VP, Longo VD. Aging as a mitochondria-mediated atavistic program: can aging be switched off? Ann N Y Acad Sci. 2005 Dec;1057:145-64. doi: 10.1196/annals.1356.009. PMID: 16399892.

The Journal of Cell Biology / 1997
Human Bcl-2 Reverses Survival Defects in Yeast Lacking
Superoxide Dismutase and Delays Death of Wild-Type Yeast